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Combination Drug or Dual Release Approaches

Combination drugs are increasingly being developed to improve therapeutic effect and patient compliance. Dual-release profiles are also being sought for pulsatile- or combination-release functionality to target more than one area of the GI tract.
Combination Drug or Dual Release Approaches

Capsugel Dosage Form Solutions offers several approaches to achieve combination-drug or dual-release functionality in a single dosage unit: 

Capsugel liquid fill capsule-in-capsule technology provides proven capability for novel line extensions and is suited for pharmaceutical and nutraceutical applications. The capsule-in-capsule technology represents an advancement of our premier liquid-fill hard-capsule technology.

Capsule-in-capsule technology involves specialized liquid-filling techniques using custom-designed filling equipment that allows a prefilled, smaller capsule to be inserted into a larger, liquid-filled capsule. The smaller inner capsule may contain either a liquid, solid, or semi-solid formulation and, based on the formulation or product requirements, either or both capsules may be made of gelatin or hydroxypropyl methylcellulose (HPMC) and coated, if desired.

Capsule-in-capsule technology offers broad formulation and design options, including:

It can be used to achieve:

Capsule-in-capsule formulations are manufactured using custom liquid-fill equipment and sealed with Licaps® Fusion Technology. The technology is available for pilot- and commercial-scale production in both the U.S. and Europe.

Related Links

DUOCAP Capsule-in-Capsule Technology
Health and Nutrition

Additional Resources

Capsule-in-Capsule Delivery System

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