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Colonic Delivery Technologies

Capsugel Dosage Form Solutions offers multiparticulate and capsule-coating technologies to achieve colonic drug delivery. This targeted delivery option has received increased attention not only for treatment of colon-specific diseases such as irritable bowel disease (IBD), but also to take advantage of the colon’s absorptive surface area and conditions to deliver specific drugs and treat specific indications.
Colonic Delivery Technologies

Capsugel has successfully used a variety of formulation strategies, tailored to the needs of the specific drug or problem statement, to achieve colonic drug delivery, including: 

One of the challenges to successful colonic delivery is the relatively small amount of water available for dissolution of dosage forms in the colon. The combination of reliable targeting technology and the delivery of drugs in a liquid dosage form can provide an optimal approach for colonic delivery.

We have successfully used these colonic-delivery formulations in liquid fill format for a number of development projects, progressing formulations into preclinical and clinical studies.

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Targeting the colon with liquid-filled capsules

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Colonic Delivery Technology

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