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Capsugel Dosage Form Solutions developed enTRinsic™ drug delivery technology to provide oral delivery with full enteric protection and rapid release in the upper gastrointestinal (GI) tract without the use of coatings. enTRinsic™ capsules are manufactured using pharmaceutical grades of cellulosic enteric derivatives (100%). This novel and proprietary technology has proven in vitro and in vivo performance, and is finding application in several areas:
Some products are difficult or impossible to delivery orally due to the need for enteric protection, but the inability to withstand either the high temperatures associated with coating application and/or sensitivity to the coating solution or suspension.enTRinsic™ drug delivery technology can therefore be enabling for oral delivery providing full enteric protection without coating, and applicable to a range of sensitive molecules:
enTRinsic™ drug delivery technology has been shown to rapidly release at pH 5.5 allowing optimal absorption in the upper GI tract.
enTRinsic™ drug delivery technology can be utilized to greatly simplify and accelerate prototype development and rapid in vivo testing of products requiring enteric protection and/or targeted release to the upper GI tract:
Independent analysis estimates time savings afforded by enTRinsic™ drug delivery technology of 9 months or more through Phase III.