Liquid Fill Hard Capsule Manufacturing
Liquid fill and semi-solid fill technology and manufacture are core strengths of Capsugel Dosage Form Solutions.
Over the last twenty years, we have built an unrivalled level of experience and track record in the liquid filling of hard shell capsules. Capsugel Dosage Form Solutions has manufacturing sites in the U.S., Europe and Asia producing billions of soft gelatin and liquid-fill hard capsule (LFHC) formulations annually for the pharmaceutical and health & nutrition market segments. More than 25 commercial pharmaceutical liquid fill hard capsule products have been produced as well as hundreds of health and nutrition products.
Our focus on science & engineering has led to the development of proprietary equipment and processing techniques, to provide optimal efficiency, reliability and productivity for our LFHC clients.
- Optimized capsule design to increase mechanical strength
- High precision liquid dosing pump can handle free-flowing to highly viscous suspensions
- Proprietary fusion sealing technology allows high efficiency capsule handling and sealing; optional capsule banding
- New automated on-line systems for 100% inspection

Specialized liquid filling and sealing equipment has also been engineered for lab and pilot scale manufacturing of liquid fill hard capsule dosage forms. Banding capability is also in place as a capsule sealing option.
Infrastructure Overview
- Five commercial manufacturing sites in the U.S., EU and Japan
- Co-located product development, pilot and commercial scale manufacturing
- Feasibility, stability and clinical batch supply
- Non-GMP and GMP facilities with separate clean room suites
- FDA/MHRA inspected and accredited sites
- Specialized manufacturing for cytotoxics, antibiotics, peptides and high potency compounds
- High containment capability to OEB 5
- Capsule coating as an additional lever for modified release and colonic delivery
- Banding or proprietary Licaps Fusion technology for optimized LFHC sealing efficiency
- Primary and secondary packaging
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